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The screening for anti-nuclear antibodies (ANAs) performed on human epithelial (HEp-2) cells by indirect immunofluorescence (IIF) tests is the gold standard method in the diagnostic approach to systemic rheumatic disorders recommended by both the European and the American guidelines. The need for standardized and reproducible evaluation of cell-based IIF assays that overcome the disadvantages of classic assay have guided autoimmunity laboratories on the road to automation.
The Zenit G-Sight systems from A. Menarini Diagnostics for image acquisition and interpretation of cell- or tissue-based IIF tests are ideal for the automated serological diagnosis of autoimmune diseases.
Conceived as an entry-level instrument for its relatively low cost (30-35% less than Zenit G-Sight Classic), Zenit G-Sight Twice has the same performance of the other instruments but less autonomy for the analysis: the motorized scan stage holds 2 slides. In case of high workload, the operator simply needs to load the slides more frequently.
Zenit G-Sight Classic is the prototype among the Zenit G-Sight Systems. It is a cost-effective tool for laboratories with a heavy workload. Its motorized scan stage holds up to 8 slides maximizing efficiency and optimizing human resources.
A positive ANA result is used as an initial stepping stone for detecting the specific autoantibodies underlying the IIF reaction using micro-array (From 2013 Euromedlab Congress - abstract EW080). Zenit G-Sight AMiDot is the only existing instrument, that can read both IIF and AMiDot slides combining the high screening efficiency of Zenit G-Sight with micro-array technology.
A state-of-the-art automated fluorescence microscope with highly focused LED light source, virtually maintenance free, generating little heat and not photobleaching FITC as fast as mercury lamps do
A motorized scanning stage for substrate slides. Zenit G sight’s XY-motorized scan stage holds up to 8 slides (containing various number of wells) and is equipped with a barcode reader. For maximizing accuracy, a large area is scanned (from 1 to 220 fields per well).
The high-sensitivity CCD camera of the Zenit G sight system captures clear, high-contrast fluorescence images.
Since its founding in 1976, A. Menarini Diagnostics has distinguished itself as one of Europe's leading diagnostics companies by offering healthcare professionals cutting edge, hi-tech solutions in line with their diagnostics needs. For over 35 years, A. Menarini Diagnostics has proven to be a flexible and trustworthy partner, providing the market with top quality products and after sales services and guaranteeing an extensive and longstanding knowledge of today’s markets and expectations. A. Menarini Diagnostics: more than three decades dedicated to exceeding the technological needs of Europe’s most prominent healthcare professionals in the fields of diabetes (both Home Glucose Testing and laboratory testing), autoimmunity, urinalysis and cell pathology, as well as enhancing the quality of life of patients all around the world.